Practice parameter for inborn errors of immunity: What is new in the 2025 update.

The Practice Parameter for Inborn Errors of Immunity was revised in 2025 and published recently. We reviewed the most significant changes of this update regarding the previous parameter update in 2015. In contrast to previous revisions focused on individual genetic entities, this update was written with a new structure of recommendations divided into 2 parts: diagnosis and management. The diagnosis part includes discussions of newborn screening for severe combined immunodeficiency, genetic testing, and surveillance of comorbidities, in addition to reviewing clinically available testing for immunologic diagnosis. The management part includes recommendations for immunoglobulin replacement, antibiotic prophylaxis, hematopoietic stem cell transplantation, precision medicine, and quality-of-life assessment.