Fertility and sterility · 2009
Progestogen treatments for cycle management in a sheep model of assisted conception affect the growth patterns, the expression of luteinizing hormone receptors, and the progesterone secretion of induced corpora lutea.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Letelier Claudia, García-Fernández Rosa Ana, Contreras-Solis Ignacio, Sanchez María Angeles, Garcia-Palencia Pilar, Sanchez Belen, Gonzalez-Bulnes Antonio, Flores Juana María
Аннотация
OBJECTIVE: To determine, in a sheep model, the effect of a short-term progestative treatment on growth dynamics and functionality of induced corpora lutea.
DESIGN: Observational, model study.
SETTING: Public university.
PATIENT(S): Sixty adult female sheep.
INTERVENTION(S): Synchronization and induction of ovulation with progestogens and prostaglandin analogues; ovarian ultrasonography, blood sampling, and ovariectomy.
MAIN OUTCOME MEASURE(S): Determination of pituitary function and morphologic characteristics, expression of luteinizing hormone (LH) receptors, and progesterone secretion of corpora lutea.
RESULT(S): The use of progestative pretreatments for assisted conception affect the growth patterns, the expression of LH receptors, and the progesterone secretion of induced corpora lutea.
CONCLUSION(S): The current study indicates, in a sheep model, the existence of deleterious effects from progestogens on functionality of induced corpora lutea.
DESIGN: Observational, model study.
SETTING: Public university.
PATIENT(S): Sixty adult female sheep.
INTERVENTION(S): Synchronization and induction of ovulation with progestogens and prostaglandin analogues; ovarian ultrasonography, blood sampling, and ovariectomy.
MAIN OUTCOME MEASURE(S): Determination of pituitary function and morphologic characteristics, expression of luteinizing hormone (LH) receptors, and progesterone secretion of corpora lutea.
RESULT(S): The use of progestative pretreatments for assisted conception affect the growth patterns, the expression of LH receptors, and the progesterone secretion of induced corpora lutea.
CONCLUSION(S): The current study indicates, in a sheep model, the existence of deleterious effects from progestogens on functionality of induced corpora lutea.