[Pathogenesis of autoimmune hepatitis].

OBJECTIVES

The aim of the study was to review the pathogenic mechanisms of auto-immune hepatitis.

METHODS

The study was based on a review of all relevant articles from literature on the mechanisms of auto-immunity in auto-immune hepatitis.

RESULTS

The precise mechanisms through which liver damage occurs are not fully understood. Auto-immune hepatitis seems to be a consequence of auto-antigen exposure, genetic predisposition and defective immuregulatory mechanisms. Auto-antigen is presented by class II molecules of the major histocompatibility complex. Cytokines and non specific auto-immune promotors modulate immune reactivity. Cell-mediated and antibody-dependent forms of cytotoxicity are probably interactive pathogenic mechanisms.

CONCLUSION

Disturbance in the tight balance between auto-aggression and self-tolerance, affected by several internal and external factors are likely in auto-immune hepatitis.