Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2004
The fluorescence of thyroid tissue.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Pitman Michael Jay, Rosenthal Joshua Michael, Savage Howard E, Yu Goupei, McCormick Steven A, Katz Alvin, Alfano Robert R, Schantz Stimson Pryor
Аннотация
OBJECTIVE: To investigate the fluorescent characteristics of different thyroid tissues.
STUDY DESIGN: Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios.
RESULTS: Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively.
CONCLUSION: Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies.
SIGNIFICANCE: This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration.
EBM RATING: B-3.
STUDY DESIGN: Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios.
RESULTS: Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively.
CONCLUSION: Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies.
SIGNIFICANCE: This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration.
EBM RATING: B-3.