Breast cancer research : BCR · 2024
Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Strand Siri H, Houlahan Kathleen E, Branch Vernal, King Lorraine M, Lynch Thomas, Rivero-Guitiérrez Belén, Harmon Bryan, Couch Fergus, Gallagher Kristalyn, Kilgore Mark, Wei Shi, DeMichele Angela, King Tari, McAuliffe Priscilla, Curtis Christina, Owzar Kouros, Marks Jeffrey R, Colditz Graham A, Hwang E Shelley, West Robert B
Аннотация
BACKGROUND: Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.
METHODS: We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.
RESULTS: Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.
CONCLUSIONS: Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.
METHODS: We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.
RESULTS: Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.
CONCLUSIONS: Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.
Предметные рубрики MeSH
AdultAgedFemaleHumansMiddle AgedBiomarkers, TumorBlack or African AmericanBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCase-Control StudiesDNA Copy Number VariationsGene Expression ProfilingGene Expression Regulation, NeoplasticPrognosisErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenSelf ReportTumor MicroenvironmentWhite