Prostaglandins, leukotrienes, and essential fatty acids · 2026
Impact of perinatal α-linolenic acid deficiency combined with high-fat diet consumption on tissue-specific fatty acid profiles in rats: Maternal and offspring analysis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Beyer María Paz, Mercado-Lopez Lorena, Farias Camila, Carrasco-Gutiérrez Robinson, Espinosa Alejandra, Dagnino-Subiabre Alexies, Muñoz Yasna, E Ignacio Alvear, Videla Luis A, Valenzuela Rodrigo
Аннотация
BACKGROUND: An imbalance in the dietary ratio of omega-6 (n-6) to omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and/or a high-fat diet (HFD) may disrupt the metabolic conversion of essential PUFAs, such as linoleic acid (LA) and α-linolenic acid (ALA), into their long-chain derivatives (LC-PUFAs), thereby altering their accumulation in various tissues. To determine the effects of low maternal intake of ALA and/or an HFD on FA composition in maternal tissues (liver, adipose tissue, and erythrocytes) and offspring tissues (liver, erythrocytes, adipose tissue, heart, kidney, intestine, muscle, brain, eye, lung, and stomach contents) in rats.
METHODS: A prospective, randomized, controlled experimental study was conducted in Sprague-Dawley rats. Animals were assigned to one of four dietary intervention groups: CD-<1%-ALA, CD-2%-ALA, HFD-<1%-ALA, and HFD-2%-ALA. The diets were administered throughout the pregestational, gestational, and postnatal periods. Following euthanasia, tissue samples were collected and analyzed for FA composition using gas chromatography.
RESULTS: The accumulation of n-3 PUFAs varied across the analyzed tissues, suggesting tissue-specific uptake or incorporation of ALA. The liver exhibited the highest capacity for PUFA biosynthesis in rats, whereas extrahepatic tissues showed limited activity. Moreover, maternal diet did not consistently correlate with PUFA concentrations in the offspring.
CONCLUSIONS: The increase in ALA is tissue-specific, reflecting differential incorporation among tissue types. Maternal n-3 PUFA stores become a critical source for the transfer of these FAs to the offspring, particularly under dietary stress conditions such as low ALA intake or HFDs.
METHODS: A prospective, randomized, controlled experimental study was conducted in Sprague-Dawley rats. Animals were assigned to one of four dietary intervention groups: CD-<1%-ALA, CD-2%-ALA, HFD-<1%-ALA, and HFD-2%-ALA. The diets were administered throughout the pregestational, gestational, and postnatal periods. Following euthanasia, tissue samples were collected and analyzed for FA composition using gas chromatography.
RESULTS: The accumulation of n-3 PUFAs varied across the analyzed tissues, suggesting tissue-specific uptake or incorporation of ALA. The liver exhibited the highest capacity for PUFA biosynthesis in rats, whereas extrahepatic tissues showed limited activity. Moreover, maternal diet did not consistently correlate with PUFA concentrations in the offspring.
CONCLUSIONS: The increase in ALA is tissue-specific, reflecting differential incorporation among tissue types. Maternal n-3 PUFA stores become a critical source for the transfer of these FAs to the offspring, particularly under dietary stress conditions such as low ALA intake or HFDs.