EJIFCC · 2025
Inflammation: The Mother of All Diseases Meets the Mother of All Therapies.
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Chatanaka Miyo K, Diamandis Eleftherios P
Аннотация
INTRODUCTION: Incretins are small peptides secreted by the gastrointestinal tract. These peptides exert their action by binding to G-protein-coupled receptors that are widely distributed in the pancreas, throughout the gastrointestinal tract, and the brain. The physiological role of incretins (such as GLP-1) is to regulate glucose levels by increasing insulin secretion, delaying gastric emptying, and decreasing appetite, leading to weight loss.
METHOD: In this review, we aimed to report the effects of inflammation on human health and how GLP-1 and GLP-1 receptor agonists, which are now being used as first-line agents to control obesity, can have a broader effect on human diseases.
RESULTS: The literature shows the benefits of these drugs in diseases other than obesity, including in diseases of many organs such as heart, kidneys, liver, blood vessels, and in neurodegenerative and psychiatric conditions. These diverse beneficial effects are attributed to the anti-inflammatory activities of these new drugs.
CONCLUSIONS: The physiological actions of incretins have recently been better understood. The surprisingly diverse therapeutic activities of this class of new drugs suggest that they will likely play central roles not only in the management of type-2 diabetes but for the treatment of obesity and a wide spectrum of diseases for which inflammation is a major factor.
METHOD: In this review, we aimed to report the effects of inflammation on human health and how GLP-1 and GLP-1 receptor agonists, which are now being used as first-line agents to control obesity, can have a broader effect on human diseases.
RESULTS: The literature shows the benefits of these drugs in diseases other than obesity, including in diseases of many organs such as heart, kidneys, liver, blood vessels, and in neurodegenerative and psychiatric conditions. These diverse beneficial effects are attributed to the anti-inflammatory activities of these new drugs.
CONCLUSIONS: The physiological actions of incretins have recently been better understood. The surprisingly diverse therapeutic activities of this class of new drugs suggest that they will likely play central roles not only in the management of type-2 diabetes but for the treatment of obesity and a wide spectrum of diseases for which inflammation is a major factor.