Survival rate of pancreatic cancer in Asian countries: A systematic review and meta-analysis.

BACKGROUND

So far, no comprehensive study has been conducted regarding the survival rate of pancreatic cancer patients in Asia; Therefore, according to the mentioned points, the present study was designed with the aim of conducting a systematic review to calculate the survival rate of pancreatic cancer in Asian countries in 2024.

METHODS

This research is a systematic review and meta-analysis. The researchers of this study examined the articles published in 5 international databases including Medline/PubMed, Scopus, Google Scholar, Web of knowledge and ProQuest. Preparation for data analysis was based on content analysis of the Newcastle-Ottawa Quality Assessment Form. Due to the existence of heterogeneity (with a significance level of <0.1 and I2 >50%), the random effects model was used with the reverse variance method. Meta-regression was also performed for the HDI index. All analyzes were performed by CMA version 2 statistical software.

RESULTS

Finally, 27 articles were selected to enter the meta-analysis model. The 1-year survival rate of pancreatic cancer was estimated to be 27.6% (95% CI: 24.2%-31.2%). The 5-year survival rate for both sexes was 9.7% (95% CI: 8.8%-10.6%). The estimated 5-year survival rates in men and women were 9.3% (95% CI:8.3%-10.4%) and 10.4% (95% CI: 10.2%-10.7%), respectively. The results of the meta-regression model showed that there is a significant relationship between Human Development Index (HDI) and pancreatic cancer survival rate (point estimate of slope: 4.73, standard error: 0.11, P-value < .001).

CONCLUSION

Overall, the 1- and 5-year survival rates for pancreatic cancer in Asian countries were 27.6% and 9.7%, respectively. This rate was lower than in the United States. It seems that the design, implementation, monitoring and planning of integrated diagnostic and treatment services in Asian countries can greatly increase the survival of pancreatic cancer in the coming decades.