Nature communications · 2019
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Abdulhaqq Shaheed A, Martinez Melween, Kang Guobin, Rodriguez Idia V, Nichols Stephanie M, Beaumont David, Joseph Jocelin, Azzoni Livio, Yin Xiangfan, Wise Megan, Weiner David, Liu Qin, Foulkes Andrea, Münch Jan, Kirchhoff Frank, Coutifaris Christos, Tomaras Georgia D, Sariol Carlos, Marx Preston A, Li Qingsheng, Kraiselburd Edmundo N, Montaner Luis J
Аннотация
Semen is the vehicle for virion dissemination in the female reproductive tract (FRT) in male-to-female HIV transmission. Recent data suggests that higher frequency semen exposure is associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, we use a non-human primate (NHP) model to show that repeated vaginal exposure to semen significantly reduces subsequent infection by repeated low-dose vaginal SIVmac251 challenge. Repeated semen exposures result in lower CCR5 expression in circulating CD4+ T-cells, as well as higher expression of Mx1 (in correlation with IFNε expression) and FoxP3 in the cervicovaginal mucosa, and increased infiltration of CD4+ T-cells. Establishing in vivo evidence of competing effects of semen on transmission impacts our basic understanding of what factors may determine HIV infectivity in humans. Our results clearly indicate that repeated semen exposure can profoundly modulate the FRT microenvironment, paradoxically promoting host resistance against HIV acquisition.