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DOI 10.21873/anticanres.13634

Медицинская библиотека · Anticancer research · 2019

Clinical and Prognostic Significance of Neoplastic Spindle Cells in Gallbladder Cancer.

Midorikawa Ryuta, Hisaka Toru, Sakai Hisamune, Nomura Yoriko, Goto Yuichi, Sato Toshihiro, Kawahara Ryuichi, Ishikawa Hiroto, Fujita Fumihiko, Yasunaga Masafumi, Tanigawa Masahiko, Naito Yoshiki, Akiba Jun, Yano Hirohisa, Tanaka Hiroyuki, Akagi Yoshito, Okuda Koji

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Аннотация

BACKGROUND/AIM: Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer.

MATERIALS AND

METHODS

Specimens were obtained from 62 patients with gallbladder cancer who underwent surgery. The emergence of NSCs and their correlation with clinicopathological factors, prognosis, and EMT markers was evaluated.

RESULTS

The NSC grade correlated with tumor size, preoperative CA19-9, surgical margin, the degree of differentiation, the depth of invasion, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion. Multivariate analysis of overall survival showed that NSCs were an independent prognostic factor. A correlation between NSCs and EMT was also suggested.

CONCLUSION

NSCs are an independent prognostic factor for patients with postoperative gallbladder cancer, which also suggests a correlation between NSCs and EMT.

Для цитирования: Midorikawa Ryuta, Hisaka Toru, Sakai Hisamune, Nomura Yoriko, Goto Yuichi, Sato Toshihiro, Kawahara Ryuichi, Ishikawa Hiroto, Fujita Fumihiko, Yasunaga Masafumi, Tanigawa Masahiko, Naito Yoshiki, Akiba Jun, Yano Hirohisa, Tanaka Hiroyuki, Akagi Yoshito, Okuda Koji. Clinical and Prognostic Significance of Neoplastic Spindle Cells in Gallbladder Cancer.. Anticancer research. 2019. DOI: 10.21873/anticanres.13634.

Предметные рубрики MeSH

AdultAgedBiomarkers, TumorCA-19-9 AntigenEpithelial CellsEpithelial-Mesenchymal TransitionFemaleGallbladder NeoplasmsHumansKaplan-Meier EstimateLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm InvasivenessPrognosis
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