[Prevention of reserpine induced experimental gastric ulcer in rat with amoxicillin a report of preliminary controlled study].

In recent years, amoxicillin (A) has been proved very effective in clearing helicobacter pylor (HP) and promoting ulcer healing. Is the cure due solely to the clearance of HP? Forty three Wistar rats were randomized into four groups to investigate the efficacy of A in preventing the experimental ulcer induced by reserpine and compare it with that of ranitidine (R) and antacid weishuping (W). A normal saline (NS) group was used as control. The total numbers of ulcer induced per rat for the NS, W, R and A groups were 7.8 +/- 5.1, 2.2 +/- 3.2, 1.0 +/- 1.2 and 2.1 +/- 1.9, respectively. The ulcer indices were 20.8 +/- 13.2, 4.5 +/- 7.7, 2.0 +/- 3.7 and 4.5 +/- 3.9, respectively. No HP was identified. The results indicated that A, R and W were all effective in preventing reserping induced ulcer with no significant difference (P > 0.05); they were significantly more effective than NS (P < 0.05). Since A is not an antacid and no HP existed in the experimental rats, there must be a mechanism of A involved in the prevention of experimental ulcer.