Медицинская библиотека · Nature human behaviour · 2026

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.

de Hoyos Lucía, Schlag Fenja, Jahagirdar Sanjeevan, Corfield Elizabeth C, Allegrini Andrea G, Admiraal Danielle, de Zeeuw Eveline L, Nolte Ilja M, Llonga Natalia, Neumann Alexander, Lange Katherine, van den Bedem Simone, Du Rietz Ebba, Motazedi Ehsan, Eising Else, Ng Nicole Y T, Palviainen Teemu, Wang Carol A, Thiering Elisabeth, Scatolin Sofia, Choudhary Priyanka, Vilor-Tejedor Natalia, Liao Zhijie, Alemany Silvia, Pedersen Casper-Emil T, Fernandez-Jimenez Nora, Campbell Megan L, Girchenko Polina, Barthome Eli, Martin L Caitlin, Seelemeyer Hanna, Kumar Afsheen, Jeanne Alexandre, Ahluwalia Tarunveer S, Black Melissa H, Buitelaar Jan K, Fisher Simon E, Heiskala Anni, Hernández-Lorca María, Jaddoe Vincent W, Järvelin Marjo-Riitta, Koopowitz Sheri-Michelle, Lake Marilyn T, Lichtenstein Paul, Llop Sabrina, Luo Mannan, Malmberg Anni, Marí Sergi, Oldehinkel Albertine J, Pausova Zdenka, Pennell Craig E, Plomin Robert, Reichborn-Kjennerud Ted, Reilly Sheena, Rodriguez Alina, Rolland Thomas, Ronald Angelica, Räikkönen Katri, Shin Jean, Artigas María Soler, Tate Ashley E, Tiemeier Henning, Verhoef Ellen, Vuoksimaa Eero, Wake Melissa, Warrier Varun, Ystrom Eivind, Bölte Sven, Ecker Christine, Bourgeron Thomas, Lahti Jari, Stein Dan J, Bilbao Jose Ramon, Bønnelykke Klaus, Bustamante Mariona, Paus Tomas, Middeldorp Christel M, Sunyer Jordi, Sebert Sylvain, Standl Marie, Whitehouse Andrew J O, Kaprio Jaakko, Ramos-Quiroga J Antoni, Ribases Marta, Casas Miguel, Bosch Rosa, Morgan Angela T, Vrijkotte Tanja G M, Larsson Henrik, Cecil Charlotte A M, Hartman Catharina A, Boomsma Dorret I, Rimfeld Kaili, Havdahl Alexandra, St Pourcain Beate

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Аннотация

Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour from infancy to early adulthood, studying ~500,000 repeated measures in European-ancestry cohorts (N = 73,321). We modelled heterogeneity in single-variant associations across social domains (low prosocial behaviour and peer/social difficulties), multiple informants (parents, teachers and self-reports) and ages (2-29 years), identifying 6 associated loci, including variation within CADM2 (P = 2.51 × 10-9). Single nucleotide polymorphism-based heritability ranged from 2% to 7%, and the genetic architecture comprised 4 factors reflecting differences in either social domains or informants. Polygenic scores (N = 16,305) accurately predicted contextual variation in independent cohorts, with some cross-ancestry transferability. Context-specific patterns of genetic correlations, particularly when estimating the developmental onset of associations, offer opportunities to disentangle shared trajectories linking social behaviour with later-life and mental health outcomes.

Для цитирования: de Hoyos Lucía, Schlag Fenja, Jahagirdar Sanjeevan, Corfield Elizabeth C, Allegrini Andrea G, Admiraal Danielle, de Zeeuw Eveline L, Nolte Ilja M, Llonga Natalia, Neumann Alexander, Lange Katherine, van den Bedem Simone, Du Rietz Ebba, Motazedi Ehsan, Eising Else, Ng Nicole Y T, Palviainen Teemu, Wang Carol A, Thiering Elisabeth, Scatolin Sofia, Choudhary Priyanka, Vilor-Tejedor Natalia, Liao Zhijie, Alemany Silvia, Pedersen Casper-Emil T, Fernandez-Jimenez Nora, Campbell Megan L, Girchenko Polina, Barthome Eli, Martin L Caitlin, Seelemeyer Hanna, Kumar Afsheen, Jeanne Alexandre, Ahluwalia Tarunveer S, Black Melissa H, Buitelaar Jan K, Fisher Simon E, Heiskala Anni, Hernández-Lorca María, Jaddoe Vincent W, Järvelin Marjo-Riitta, Koopowitz Sheri-Michelle, Lake Marilyn T, Lichtenstein Paul, Llop Sabrina, Luo Mannan, Malmberg Anni, Marí Sergi, Oldehinkel Albertine J, Pausova Zdenka, Pennell Craig E, Plomin Robert, Reichborn-Kjennerud Ted, Reilly Sheena, Rodriguez Alina, Rolland Thomas, Ronald Angelica, Räikkönen Katri, Shin Jean, Artigas María Soler, Tate Ashley E, Tiemeier Henning, Verhoef Ellen, Vuoksimaa Eero, Wake Melissa, Warrier Varun, Ystrom Eivind, Bölte Sven, Ecker Christine, Bourgeron Thomas, Lahti Jari, Stein Dan J, Bilbao Jose Ramon, Bønnelykke Klaus, Bustamante Mariona, Paus Tomas, Middeldorp Christel M, Sunyer Jordi, Sebert Sylvain, Standl Marie, Whitehouse Andrew J O, Kaprio Jaakko, Ramos-Quiroga J Antoni, Ribases Marta, Casas Miguel, Bosch Rosa, Morgan Angela T, Vrijkotte Tanja G M, Larsson Henrik, Cecil Charlotte A M, Hartman Catharina A, Boomsma Dorret I, Rimfeld Kaili, Havdahl Alexandra, St Pourcain Beate. Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.. Nature human behaviour. 2026. DOI: 10.1038/s41562-026-02551-z.

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