Cancer risks for ATM variant heterozygotes.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Jiao Yue, Goldgar David E, Le Gal Dorothée, Cavaciuti Eve, Beauvallet Juana, Dondon Marie-Gabrielle, Eon-Marchais Séverine, Le Gall Jessica, Dubois d'Enghien Catherine, Delhomelle Hélène, Warcoin Mathilde, Kluna Arjeta, Buecher Bruno, Castéra Laurent, Colas Chrystelle, Crivelli Louise, Cusin Veronica, Garrec Céline, Golmard Lisa, Popovici Cornel, Sevenet Nicolas, Al Saati Ayman, Zattara-Cannoni Hélène, Combes Audrey, Coupier Isabelle, GGC investigators, Lemonnier Jérôme, Caron Olivier, Stoppa-Lyonnet Dominique, Andrieu Nadine, Lesueur Fabienne
Аннотация
METHODS: Data were collected on 141 ataxia-telangiectasia families, 398 hereditary breast and ovarian cancer families, and 96 families with a history of pancreatic cancer enrolled in French nation-wide epidemiological studies CoF-AT2, TUMOSPEC, or GENESIS. Hazard ratios (HR) and cumulative risks were estimated using a modified segregation analysis method.
RESULTS: An increased risk of breast and pancreatic cancers was observed for PV/PPV heterozygotes, and HRs were similar in the 3 family sets. When combined, HR were 4.0 (95% CI: 2.9-5.6) for female breast cancer, 6.6 (95% CI: 3.6-12.1) for female pancreatic cancer, and 2.8 (95% CI: 1.4-5.5) for male pancreatic cancer. In birth cohort 1960 to 1969, female heterozygotes had a cumulative risk of breast cancer of 9.9% (95% CI: 7.1%-13%) by age 50, and of 40% (95% CI: 31%-51%) by age 80. Their risk of pancreatic cancer by age 80 was 8.1% (95% CI: 4.3%-14%). The risk of male pancreatic cancer by age 80 was 5.1% (95% CI: 2.4%-9.3%). No increased risk of ovarian and prostate cancers was observed.
CONCLUSION: Our findings will help in the clinical management of families in which an ATM PV/PPV segregates.