Gastroenterology · 2015
Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Lee Guan-Huei, Tan Boon-Huan, Teo Esmeralda Chi-Yuan, Lim Seng-Gee, Dan Yock-Young, Wee Aileen, Aw Pauline Poh Kim, Zhu Yuan, Hibberd Martin Lloyd, Tan Chee-Kiat, Purdy Michael A, Teo Chong-Gee
Аннотация
There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared it with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, therefore camelid HEV, which is genotype 7, might infect human beings. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.