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Войти в исследования Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2015
[HCV Genotype Distribution in Southwest China and Its Influence on Patients' Response to Pegylated-interferon α-2a Plus Ribavirin Therapy].
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Аннотация
OBJECTIVE: To study the distribution of hepatitis C virus (HCV) genotype in Sichuan population and to investigate the effects of HCV genotypes on the viral response of hepatitis C patients treated with pegylated interferon α-2a plus ribavirin as well as the relationship between HCV genotype and the severity of disease.
METHODS: 189 patients with HCV infection were enrolled. The level of serum HCV-RNA at various points during the treatment was measured while HCV genotypes and baseline serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) were detected.
RESULTS: The genotype of HCV in Sichuan population is dominated by genotype-1 (which accounting for 79.89%), while the other genotypes accounting for 20.11%. Patients with genotype-1 infection have lower end-oftreatment virological response (ETVR) rates and early virological response (EVR) compared with non-genotype-1 patients (P< 0 . 5). But the disease-associated indexes between these two groups have no significant differences. CCONCLUSION: he distribution of the HCV genotypes in Sichuan population has certain regularity, dominated by HCV genotype-1 infection. We confirmed that HCV genotype can be a predictive factor of the virological response of the standard antiviral treatment.
METHODS: 189 patients with HCV infection were enrolled. The level of serum HCV-RNA at various points during the treatment was measured while HCV genotypes and baseline serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) were detected.
RESULTS: The genotype of HCV in Sichuan population is dominated by genotype-1 (which accounting for 79.89%), while the other genotypes accounting for 20.11%. Patients with genotype-1 infection have lower end-oftreatment virological response (ETVR) rates and early virological response (EVR) compared with non-genotype-1 patients (P< 0 . 5). But the disease-associated indexes between these two groups have no significant differences. CCONCLUSION: he distribution of the HCV genotypes in Sichuan population has certain regularity, dominated by HCV genotype-1 infection. We confirmed that HCV genotype can be a predictive factor of the virological response of the standard antiviral treatment.