A novel adjunct for COPD: Could it be type II inflammation?

Chronic obstructive pulmonary disease (COPD) is a disease of the lungs characterized by irreversible airflow obstruction that has primarily been associated with neutrophilia; however, emerging evidence suggests an eosinophilic component in some patients. Management for COPD has focused on smoking cessation, pollutant avoidance, and inhaled therapy, but unfortunately, these carry therapeutic limitations for some patients. Biologic therapy has been an asthma treatment staple for years; however, it was not found to be beneficial for COPD until recently. In 2025, two biologic therapies were approved for patients with COPD and an eosinophilic phenotype.