Indian journal of pathology & microbiology · 2026
Prognostic significance of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in glottic laryngeal cancer.
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Muhedin Kadic, Elvir Zvrko, Ljiljana Vuckovic, Sabina Catic, Danilo Pot
Аннотация
AIM: The study aims to investigate the prognostic significance of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) expression in glottic laryngeal carcinoma (LC) and assess the correlation of their expression.
MATERIALS AND METHODS: For this study, 40 patients who underwent complete resection of the glottic laryngeal tumor as primary treatment were selected. PD-L1 and TIL expression levels were determined by immunohistochemistry.
RESULTS: Disease-free survival (DFS) was statistically significantly longer in patients with the combined positive score (CPS). CPS ≥1 than those with CPS <1. The concentration of TILs in tumor specimens was not significantly related to gender, age, T status, N status, tumor, node, metastasis (TNM) stage, pathological grade, or locoregional recurrence. Multivariate Cox regression analysis showed that low CPS and positive nodal status are statistically significant and independent predictors of malignancy recurrence.
CONCLUSIONS: The findings of our study suggest that PD-L1 could be a valuable indicator for predicting recurrence and reduced survival following definitive therapy. Consequently, further comprehensive studies involving larger groups of patients are imperative to ascertain the predictive significance of PD-L1 and TIL as biomarkers in LC.
MATERIALS AND METHODS: For this study, 40 patients who underwent complete resection of the glottic laryngeal tumor as primary treatment were selected. PD-L1 and TIL expression levels were determined by immunohistochemistry.
RESULTS: Disease-free survival (DFS) was statistically significantly longer in patients with the combined positive score (CPS). CPS ≥1 than those with CPS <1. The concentration of TILs in tumor specimens was not significantly related to gender, age, T status, N status, tumor, node, metastasis (TNM) stage, pathological grade, or locoregional recurrence. Multivariate Cox regression analysis showed that low CPS and positive nodal status are statistically significant and independent predictors of malignancy recurrence.
CONCLUSIONS: The findings of our study suggest that PD-L1 could be a valuable indicator for predicting recurrence and reduced survival following definitive therapy. Consequently, further comprehensive studies involving larger groups of patients are imperative to ascertain the predictive significance of PD-L1 and TIL as biomarkers in LC.