Head & neck · 2013
Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Szyfter Witold, Leszczyńska Małgorzata, Wierzbicka Małgorzata, Kopeć Tomasz, Bartochowska Anna
Аннотация
BACKGROUND: The aim of the study was to evaluate the treatment outcomes in the group of 108 T1b glottic cancer patients with the anterior commissure involvement treated with open horizontal glottectomy and to compare them with transoral laser microsurgery (TLM) or primary radiotherapy (XRT) results from the literature review.
METHODS: Status of surgical margins, local and nodal recurrence, organ preservation and survival rates, functional outcomes were major end points of interest.
RESULTS: Recurrence rate was 16.7% and was correlated with histologically confirmed prelaryngeal node metastases. Salvage laryngectomy was performed in 10 patients, organ preservation rate was 90.7%. Mean survival was 41.9 months, while 5-year overall survival 97.2%.
CONCLUSIONS: Local control and survival rates presented by the authors are comparable or even better than in TLM procedures or XRT outcomes from the literature. Positive prelaryngeal lymph nodes constituted a significant prognostic factor for nodal and local recurrence in the analyzed group.
METHODS: Status of surgical margins, local and nodal recurrence, organ preservation and survival rates, functional outcomes were major end points of interest.
RESULTS: Recurrence rate was 16.7% and was correlated with histologically confirmed prelaryngeal node metastases. Salvage laryngectomy was performed in 10 patients, organ preservation rate was 90.7%. Mean survival was 41.9 months, while 5-year overall survival 97.2%.
CONCLUSIONS: Local control and survival rates presented by the authors are comparable or even better than in TLM procedures or XRT outcomes from the literature. Positive prelaryngeal lymph nodes constituted a significant prognostic factor for nodal and local recurrence in the analyzed group.
Предметные рубрики MeSH
AdultAgedDeglutitionFemaleFollow-Up StudiesGlottisHumansLaryngeal NeoplasmsLaryngectomyLaser TherapyLymphatic MetastasisMaleMicrosurgeryMiddle AgedNeck DissectionNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasms, Second PrimaryOrgan Sparing TreatmentsPrognosisSalvage TherapyTracheotomyVoice Quality