Head & neck · 2013
Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Swisher-McClure Samuel, Mitra Nandita, Lin Alexander, Ahn Peter, Wan Fei, O'Malley Bert, Weinstein Gregory S, Bekelman Justin E
Аннотация
BACKGROUND: This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT).
METHODS: Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database.
RESULTS: The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037).
CONCLUSION: Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.
METHODS: Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database.
RESULTS: The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037).
CONCLUSION: Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.
Предметные рубрики MeSH
AgedCause of DeathConfidence IntervalsDisease-Free SurvivalEarly Detection of CancerFemaleFollow-Up StudiesGlottisHumansLaryngeal NeoplasmsLaryngectomyMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingProportional Hazards ModelsRadiotherapy, High-EnergyRegistriesRegression AnalysisRetrospective StudiesRisk AssessmentSEER ProgramStrokeSurvival RateTreatment Outcome