[Local recurrence of CO2 laser surgery for patients with early glottic carcinoma: a systematic review and meta-analysis].

OBJECTIVE

Using meta analysis to assess the local recurrence of CO2 laser surgery for patients with early glottic carcinoma (Tis, T1, N0, M0, T2 N0 M0).

METHOD: The Chinese data library (like Wanfang, Weipu, Chinese Periodicals library), PubMed, EMBASE, OVII) and Proquest Medical Library were searched according to including and excluding standard. The reference was screened, quality evaluated and information extracted. Meta analysis was processed by RevMan 5.0. Data including local recurrence after CO2 laser surgery for patients with stage Tis, T1 N0 M0,T2 N0 M0 glottic carcinoma was pulled using appropriate model according to their homogeneity or heterogeneity.

RESULT: A total of 27 studies were included in this meta analysis. Group Tis versus T1: P = 0.08, no statistical significance; Group T1a versus T1b: P < 0.01, great statistical significance; Group T1 versus T2: P = 0.09, no statistical significance; Group anterior commissure+ versus anterior commissure: P < 0.01, great statistical significance.

CONCLUSION

The local recurrence varies from different kinds of TNM classification of early glottic carcinoma after CO2 laser surgery. There is no statistical significance between group Tis versus T1 and group T1 versus T2. The local recurrence in T1a is lower than in T1b. The local recurrence in group anterior commissure+ is higher than in group anterior commissure+.