Clinical and histologic predictors of voice and disease outcome in patients with early glottic cancer.

OBJECTIVES/HYPOTHESIS: To determine preliminarily if clinical or histological features of patients with laryngeal dysplasia/early carcinoma correlate with voice and disease outcomes.

STUDY

DESIGN

Retrospective case series.

METHODS

All UCSF Voice Center patients treated with endoscopic surgery for severe dysplasia or early laryngeal cancer between 2004 and 2010 were identified. Preoperative stroboscopy, intraoperative appearance, and histologic characteristics (pattern of invasion, degree of inflammation, and degree of keratinization) of the neoplastic lesions were compared with cordectomy type and the outcomes of voice quality and disease-free interval.

RESULTS

Eighteen patients were evaluated. Increased stromal chronic inflammation correlated with longer disease-free interval (r(2) = 0.38). Cordectomy type correlated with both preoperative and postoperative voice parameters (r(2) = 0.42-0.68 and 0.33-0.39).

CONCLUSION

Increased stromal chronic inflammation correlates with improved disease outcome. Voice outcome correlates with the amount of tissue removed. The clinical appearance of the lesion did not correlate with disease or voice outcome.