Ultrastructural and morphometric study of regeneration dynamics in the rabbit lower jaw after Β-tricalcium phosphate transplantation.

OBJECTIVE

Aim: The aim of this study is to determine the dynamics of histoarchitectural changes in the bone-ceramic regenerate after transplantation β-tricalcium phosphate into an experimental defect in the rabbit mandible.

PATIENTS AND

METHODS

Materials and

Methods

Adult male rabbits aged 6-7 months and weighing 2.5-3 kg were used for the study. The control group consisted of animals with a bone defect that healed under a blood clot. The experimental group consisted of rabbits in which the bone defect was filled with β-tricalcium phosphate. Post-traumatic monitoring was conducted over 84 days using scanning electron microscopy and morphometric analysis of three parameters of the regenerate.

RESULTS

Results

Studying the surface relief characteristics of the experimental bone defect in the lower jaw after implantation of the β-tricalcium phosphate material revealed numerous regenerative changes that occurred after the injury and correlated with the dynamics of changes in the relative volume of bone tissue, osteoplastic material, and connective tissue in the regenerate. Morphometric analysis of the regenerate showed a phased character of the dynamics of changes.

CONCLUSION

Conclusions

The study found that the relative volume of bone tissue in the regenerate increased over time, and at the end of the experiment, it was statistically similar to the control group.