Clinical application effect of Pembrolizumab in the treatment of advanced cutaneous malignant melanoma.

OBJECTIVE

To investigate the clinical application value of Pembrolizumab (PEM) in the treatment of advanced cutaneous malignant melanoma (ACMM).

METHODS

The data of 56 patients with ACMM were retrospectively analyzed. According to the treatment methods, they were divided into a control group (30 cases) and an observation group (26 cases). Patients in the control group were given chemotherapy with Temozolomide (TEM), and patients in the observation group were treated with PEM on the basis of the treatment provided to the control group. The short-term therapeutic efficacy, long-term survival rate and the incidence of adverse reactions were compared between the two groups.

RESULTS

After treatment, the short-term clinical effective rate was higher in the observation group than that in the control group (P<0.05). In addition, the survival time in the observation group was longer than that in the control group (P<0.001); and the one-year survival rate was higher in the observation group (53.85% vs. 40.00%, P>0.05). No statistical difference was found in the incidence of adverse reactions between the two groups (P>0.05).

CONCLUSION

PEM can improve the short-term clinical effective recovery rate, long-term survival time and prognosis survival rate of patients with cutaneous malignant melanoma, with no increased incidence of drug-related adverse reactions. It is relatively safe and worthy of front-line clinical promotion and application.