Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Karabegović Irma, Portilla-Fernandez Eliana, Li Yang, Ma Jiantao, Maas Silvana C E, Sun Daokun, Hu Emily A, Kühnel Brigitte, Zhang Yan, Ambatipudi Srikant, Fiorito Giovanni, Huang Jian, Castillo-Fernandez Juan E, Wiggins Kerri L, de Klein Niek, Grioni Sara, Swenson Brenton R, Polidoro Silvia, Treur Jorien L, Cuenin Cyrille, Tsai Pei-Chien, Costeira Ricardo, Chajes Veronique, Braun Kim, Verweij Niek, Kretschmer Anja, Franke Lude, van Meurs Joyce B J, Uitterlinden André G, de Knegt Robert J, Ikram M Arfan, Dehghan Abbas, Peters Annette, Schöttker Ben, Gharib Sina A, Sotoodehnia Nona, Bell Jordana T, Elliott Paul, Vineis Paolo, Relton Caroline, Herceg Zdenko, Brenner Hermann, Waldenberger Melanie, Rebholz Casey M, Voortman Trudy, Pan Qiuwei, Fornage Myriam, Levy Daniel, Kayser Manfred, Ghanbari Mohsen
Аннотация
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10-7), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10-6). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.