In space fabrication of Janus base nano matrix for improved assembly and bioactivity.

Nanomaterials have a broad impact on both space and biomedical research but have never been produced in-space for regenerative applications. During the Axiom-2 (Ax-2) mission, our team completed the first-ever low Earth orbit (LEO) manufacturing of Janus base nanomaterials (JBNs) for cartilage tissue regeneration. This fabrication of JBNs in LEO resulted in superior product homogeneity, stability, and loading ability compared to Earth samples, demonstrating the benefits of manufacturing in microgravity.