Association of SIRT1 rs12778366 (T > C) polymorphism with reduced esophageal cancer risk: a case-control study from North India".

PURPOSE: The protein histone deacetylase silent mating-type information regulator 2 homolog 1 (SIRT1) expression has been linked to cancer prognosis. However, reports evaluating the impact of SIRT1 polymorphisms on esophageal cancer (EC) risk or prognosis are limited. The present study aimed to assess the association between SIRT1 rs12778366 polymorphism and esophageal cancer.

MATERIALS AND

METHODS

The SIRT1 rs12778366 polymorphism was evaluated by PCR-RFLP method in 244 EC patients and 244 healthy controls from Punjab, India. Odds ratios with 95% confidence intervals were used to assess the association of rs12778366 with EC risk.

RESULTS

The CC genotype (OR = 0.34, 95% CI: 0.12-0.97, p = 0.04) and the C allele (OR = 0.66, 95% CI: 0.47-0.92, p = 0.01) of the SIRT1 rs12778366 polymorphism were significantly associated with a reduced risk of esophageal cancer.

CONCLUSION

Previous studies have linked the SIRT1 rs12778366 polymorphism to susceptibility in breast, colorectal, and pituitary tumors, but its role in esophageal cancer has been minimally explored. In the present study, the CC genotype and C allele of SIRT1 rs12778366 were associated with a reduced risk of esophageal cancer in a North Indian population.