Internal medicine (Tokyo, Japan) · 2011
A case of hepatitis C-associated osteosclerosis with xanthogranulomatous cholecystitis.
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Hataya Yuji, Komatsu Yasato, Chusho Hideki, Kirishima Toshihiko, Shintani Hiroyuki, Morimoto Taisuke
Аннотация
A 62-year-old woman presented with a markedly increased serum ALP level of skeletal origin during a regular follow-up of chronic hepatitis C. Serum calcium, phosphorus, and intact-PTH levels were normal and bone turnover markers were increased. Her generalized bone density was diffusely increased. These findings were consistent with hepatitis C-associated osteosclerosis (HCAO). She underwent cholecystectomy, as gallbladder cancer was suspected; however, histopathological findings demonstrated xanthogranulomatous cholecystitis. After cholecystectomy, serum ALP level and bone turnover markers were gradually decreased. This may indicate the existence of a novel osteogenic factor in the gallbladder in HCAO.