Resuscitation · 2025
Intraventricular pressure and volume during conventional and automated head-up CPR.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pourzand Pouria, Moore Johanna, Metzger Anja, Suresh Mithun, Salverda Bayert, Hai Hamza, Duval Sue, Bachista Kerry, Debaty Guillaume, Lurie Keith
Аннотация
BACKGROUND: Active compression-decompression (ACD) CPR, an impedance threshold device (ITD) and automated head and thorax elevation, collectively termed AHUP-CPR, increases cerebral and coronary perfusion pressures, brain blood flow, end-tidal CO2 (ETCO2) and cerebral oximetry (rSO2) in animal models compared with conventional (C) CPR. We tested the hypothesis that cardiac stroke volume (SV) is higher with AHUP-CPR versus C-CPR or ACD + ITD in a porcine cardiac arrest model.
METHODS: Farm pigs (n = 14) were sedated, anesthetized, and ventilated. Hemodynamics, including biventricular pressure-volume loops, were continuously measured. Following 10 min of untreated ventricular fibrillation, C-CPR was performed for 2 min, then ACD + ITD for 2 min in the flat position, and then AHUP-CPR thereafter. Linear mixed-effects model and Pearson correlation comparisons were used for statistical analysis.
RESULTS: Coronary and cerebral perfusion pressures, ETCO2, rSO2, and right (RV) and left (LV) ventricular SV increased progressively and significantly with the implementation of AHUP-CPR (p < 0.05). RV SV with C-CPR was 24.8 ± 2.8 mL (∼48% of baseline) versus 45.2 ± 4.1 with AHUP-CPR (∼90% of baseline) (p < 0.01). LV SV with C-CPR was 17.6 ± 1.8 mL (∼35% of baseline) versus 38.7 ± 6.7 with AHUP-CPR (∼80% of baseline) (p < 0.01).
CONCLUSION: A fundamental and inherent shortcoming of C-CPR, limited cardiac stroke volume, and resultant forward flow, can be overcome with AHUP-CPR. These findings may help explain the better outcomes associated with early use of AHUP-CPR.
METHODS: Farm pigs (n = 14) were sedated, anesthetized, and ventilated. Hemodynamics, including biventricular pressure-volume loops, were continuously measured. Following 10 min of untreated ventricular fibrillation, C-CPR was performed for 2 min, then ACD + ITD for 2 min in the flat position, and then AHUP-CPR thereafter. Linear mixed-effects model and Pearson correlation comparisons were used for statistical analysis.
RESULTS: Coronary and cerebral perfusion pressures, ETCO2, rSO2, and right (RV) and left (LV) ventricular SV increased progressively and significantly with the implementation of AHUP-CPR (p < 0.05). RV SV with C-CPR was 24.8 ± 2.8 mL (∼48% of baseline) versus 45.2 ± 4.1 with AHUP-CPR (∼90% of baseline) (p < 0.01). LV SV with C-CPR was 17.6 ± 1.8 mL (∼35% of baseline) versus 38.7 ± 6.7 with AHUP-CPR (∼80% of baseline) (p < 0.01).
CONCLUSION: A fundamental and inherent shortcoming of C-CPR, limited cardiac stroke volume, and resultant forward flow, can be overcome with AHUP-CPR. These findings may help explain the better outcomes associated with early use of AHUP-CPR.