Regression of Bilateral Choroidal Metastases From Primary Lung Carcinoma in Response to Systemic Bevacizumab and Platinum Doublet.

A 58-year-old male presented with large yellowish choroidal mass lesions with exudative subretinal fluid (SRF) in both eyes. A computed tomography (CT) scan of the thorax revealed a mass lesion in the apical segment of the right upper lobe. Fine needle aspiration cytology (FNAC) of right supraclavicular lymph nodes revealed metastatic mucinous adenocarcinoma. Positron emission tomography-computed tomography scan (PET-CT) showed multiple lymphatic, pulmonary, and skeletal metastases. After six cycles of chemotherapy (platinum doublet and systemic bevacizumab), clinical examination and multimodal imaging showed complete regression of the choroidal lesions. Ours is the first case report of bilateral choroidal metastases from primary pulmonary adenocarcinoma (possibly arising from hazardous occupational exposure in the sericulture industry) that showed complete regression in response to standalone systemic chemotherapy agents, platinum doublet and systemic bevacizumab.