Neonatal and Infant Health Outcomes Following Maternal COVID-19 Vaccination: CDC's COVID-19 Vaccine Pregnancy Registry.

INTRODUCTION

The COVID-19 Vaccine Pregnancy Registry (C19VPR) monitored pregnant women vaccinated for COVID-19 during December 2020 to June 2021. We report incidence of health outcomes among infants of C19VPR participants.

METHODS

Data about birthweight (e.g., low birthweight [LBW] <2,500 grams), small-for-gestational-age (SGA), death, and 10 prespecified conditions (i.e., cardiac arrest, cardiomyopathy, congenital hearing loss, heart failure, hypoxic-ischemic encephalopathy, intussusception, myocarditis/pericarditis, seizures, stroke, and supraventricular tachycardia) were collected through phone interviews from birth through 3 months postpartum; among a subsample, interviews extended through 15 months postpartum. Incidence of each prespecified condition was compared with prepandemic estimates.

RESULTS

Of 19,852 infants with 3-month follow-up data, 125 (0.6%) had at least one prespecified condition. Estimated C19VPR incidences for these conditions, LBW, SGA, and death, were within or below ranges reported in prepandemic studies.

CONCLUSION

The incidence of LBW, SGA, death, or each of 10 prespecified infant conditions in C19VPR did not exceed prepandemic estimates.