[The local immune mechanisms of the involvement of the teeth and periodontium in periodic disease].

The aim of our investigations was to elucidate some immune aspects of combination of caries and periodontitis with periodic disease (PD), also known as familial Mediterranean fever. In this regard in patients with active and non-active stage of PD we have studied dynamic changes of concentration of secretory immunoglobulin A (SIgA) in saliva and phagocytic activity of neutrophils derived from gum blood. It has been shown that in patients with PD these indices of local immunity of oral cavity had tendency to a decrease especially in case of PD and periodontitis combination. Disturbances of local immunity was significant in active stage of PD. Based on the obtained data and analysis of latest literature data we suppose that above mentioned changes in local immunity depended on the exhaustion of adaptive properties of patients' local immunity more pronounced in case of chronic inflammation and infection foci formation in oral cavity.