European journal of gastroenterology & hepatology · 1995
Pseudomembranous colitis following clarithromycin therapy.
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Teare J P, Booth J C, Brown J L, Martin J, Thomas H C
Аннотация
OBJECTIVE: To describe the association of clarithromycin, used to treat Helicobacter pylori infection and duodenal ulceration, with pseudomembranous colitis in two patients.
SETTING: St Mary's Hospital, London, UK.
PATIENTS: Two female patients aged 77 and 78 years, admitted with duodenal ulceration and H. pylori infection.
INTERVENTION: Clarithromycin (500 mg three times daily) was administered concurrently with omeprazole (40 mg once daily).
OUTCOME MEASURES: After an initial improvement in symptoms both patients experienced persistent Clostridium difficile-associated diarrhoea.
CONCLUSIONS: High-dose clarithromycin should be used with caution for the treatment of H. pylori infection associated with gastroduodenal ulceration. The drug may induce antibiotic-associated colitis which can lead to morbidity and mortality, particularly in the elderly.
SETTING: St Mary's Hospital, London, UK.
PATIENTS: Two female patients aged 77 and 78 years, admitted with duodenal ulceration and H. pylori infection.
INTERVENTION: Clarithromycin (500 mg three times daily) was administered concurrently with omeprazole (40 mg once daily).
OUTCOME MEASURES: After an initial improvement in symptoms both patients experienced persistent Clostridium difficile-associated diarrhoea.
CONCLUSIONS: High-dose clarithromycin should be used with caution for the treatment of H. pylori infection associated with gastroduodenal ulceration. The drug may induce antibiotic-associated colitis which can lead to morbidity and mortality, particularly in the elderly.