[Omeprazole and cimetidine in the treatment of upper digestive hemorrhage].

AIM: To compare the efficacy of omeprazole (40 mgs/12 h i.v.) and cimetidine (1,200 mgs/i.v./day) in the management of upper gastrointestinal bleeding.

EXPERIMENTAL

DESIGN

Randomized, prospective open clinical trial. The end points are: mortality, surgical requirements, transfusion requirements, and length of hospitalization in Bleeding Unit and Hospital.

PATIENTS: We study patients with upper gastrointestinal bleeding from peptic sources (duodenal ulcer, gastriculcer, acute gastric erosions and peptic esophagitis). 462 patients are evaluated and 282 finally included.

RESULTS

151 patients were given cimetidine and 131 omeprazole. No significant differences in any of the end points were found.

CONCLUSIONS

The use of omeprazole does not improve cimetidine efficacy in the entire group of patients with upper gastrointestinal bleeding.