[Clinicopathological and cell immunophenotypic analysis of 54 cases of malignant nasopharyngeal/nasal lymphoma].

54 cases of nasopharyngeal/nasal non-Hodgkin's malignant lymphoma (NP/N-ML), including 41 cases of NP-ML and 13 cases of N-ML, were analyzed histologically and immunohistochemically and all of these materials were prepared in paraffin sections. They were all of diffuse type but one, of follicular type. Large cell type lymphomas were more commonly seen in this series (53.1%), and immunoblastic type with cell pleomorphism was more common in N-ML. A panel of monoclonal antibodies composed of LCA, L26, LN2, UCHL1, Leu22, Mac387 and Leu7 was used in this study. There were 27 cases exhibiting T-cell phenotype and 21 cases showing B-cell phenotype. No histiocytic type was found. The ratio of T, B cell lymphomas was different in NP-ML(T: B = 17: 18) and N-ML (T: B = 10: 3) groups, and the predominance of T-cell N-ML was obvious. Immunostaining with cytokeratin, LCA, L26, UCHL1 is of great help in differential diagnosis and immunophenotyping.