[Helicobacter pylori, 13 years after the original publication].

Helicobacter pylori a gram negative bacilli is related with development of gastroduodenal disease as chronic active gastritis, peptic ulcer disease MALT type lymphomas and gastric cancer. The WHO defined H. pylori as a human carcinogen agent. Helicobacter colonizes the gastric epithelium and promotes inflammation and mucosal damage. Third part of the world's population is infected by the bacteria and many researchers consider that the mode of transmission between human being is via the fecal-oral and/or oral-oral manner. H. pylori may be identified in saliva, gastric juice, gastric biopsies and feces by different methods. The eradication of this microorganism disminished the gastrointestinal tract disease.