Gastroenterologie clinique et biologique · 2009
Inflammatory Bowel Diseases: the genetic revolution.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Jung C, Hugot J-P
Аннотация
The genetic component of Inflammatory Bowel Diseases is among the best known for complex genetic disorders. If the functional candidate gene approach was rarely fruitful in the past, genome-wide scans allowed finding several susceptibility genes for Crohn disease including NOD2, IL23R, ATG16L1, IRGM, TNFSF15, a region close to PTGER4, PTPN2, PTPN22, NKX2-3 and many others. Only one gene, ECM1, has been reported for ulcerative colitis alone. We now need to further explore these new genes before to understand their biological role. However they clearly demonstrate the importance of innate immunity and autophagy for Crohn's disease and of the TH-17 differentiation for ulcerative colitis, Crohn's disease and other inflammatory disorders.
Предметные рубрики MeSH
Autophagy-Related ProteinsCarrier ProteinsColitis, UlcerativeCrohn DiseaseExtracellular Matrix ProteinsGTP-Binding ProteinsGenetic MarkersGenetic Predisposition to DiseaseHomeodomain ProteinsHumansInflammatory Bowel DiseasesNod2 Signaling Adaptor ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 2Protein Tyrosine Phosphatase, Non-Receptor Type 22Receptors, InterleukinReceptors, Prostaglandin E, EP4 SubtypeRisk FactorsTranscription FactorsTumor Necrosis Factor Ligand Superfamily Member 15