Emerging drugs in cutaneous T cell lymphoma.

BACKGROUND

Mycosis fungoides (MF) represents the most common type of primary cutaneous T cell-lymphomas (CTCL), which are characterized by a clonally proliferation of malignant CD4+ lymphocytes in the skin.

OBJECTIVE

Skin-directed treatment regimens, like phototherapy and corticosteroids, are commonly used in early stages; systemic treatments and chemotherapies are used in advanced stages. Because conventional treatments usually end in a transient remission without curative results, there is a high need for new therapeutic strategies with acceptable side effects.

METHODS

Literature and reference research was done by using the data bank PubMed, and updates of ongoing studies were taken out of ASCO and ASH annual meeting abstracts.

RESULTS/

CONCLUSIONS

This article gives an overview of the various medications in current use, with emphasis on emerging drugs with novel therapeutic targets.