Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2005
Angiotensin-converting enzyme I/D polymorphism in Behçet's disease.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Turgut Sebahat, Turgut Günfer, Atalay Erol Omer, Atalay Ayfer
Аннотация
OBJECTIVE: To investigate a potential relationship between I/D polymorphism within intron 16 of the angiotensin-converting enzyme (ACE) gene located on human chromosome 17 and Behçet's disease.
MATERIALS AND METHODS: Genomic DNA was obtained from 35 Turkish patients diagnosed with Behçet's disease according to the International Study Group criteria and 150 healthy individuals. Polymerase chain reaction was used to detect the presence of I and D (insertion and deletion) alleles in intron 16 of the ACE gene in these DNA samples.
RESULTS: We found differences in ACE I/D polymorphism between Behçet's disease and healthy controls (chi2=4.61, d.f.=1, p=0.044). In Behçet's disease patients, the D allele frequency was 84.3% and I allele frequency 15.7%.
CONCLUSION: An association between Behçet's disease and ACE polymorphism may provide a useful basis for future molecular studies and therapeutic approaches in this complex disease.
MATERIALS AND METHODS: Genomic DNA was obtained from 35 Turkish patients diagnosed with Behçet's disease according to the International Study Group criteria and 150 healthy individuals. Polymerase chain reaction was used to detect the presence of I and D (insertion and deletion) alleles in intron 16 of the ACE gene in these DNA samples.
RESULTS: We found differences in ACE I/D polymorphism between Behçet's disease and healthy controls (chi2=4.61, d.f.=1, p=0.044). In Behçet's disease patients, the D allele frequency was 84.3% and I allele frequency 15.7%.
CONCLUSION: An association between Behçet's disease and ACE polymorphism may provide a useful basis for future molecular studies and therapeutic approaches in this complex disease.