Медицинская библиотека · Pathology, research and practice · 2018

Evaluation of specific modified histones in lip carcinogenesis.

de Freitas Filho Silas Antonio Juvencio, Servato João Paulo Silva, de Sá Rodrigo Tavares, Siqueira Carla Silva, de Faria Paulo Rogério, Loyola Adriano Mota, Cardoso Sérgio Vitorino

СтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

Histones regulate chromatin density and therefore influence gene expression and cellular proliferation. These properties are modified by methylation, acetylation and phosphorylation of histones. The aim of this study was to investigate the variation of specific modified histones in actinic cheilitis (AC) and squamous cell carcinoma of the lip (SCCL).

METHODS

Samples of non-neoplastic tissue of the lip (NNTL, n = 9), AC (n = 33), and SCCL (n = 27) were submitted to immunohistochemistry to detect the modified histones H3K36me3, H3K9ac, H4K12ac, and H3S10 ph.

RESULTS

Reactivity for all of the modified histones was significantly decreased from NNTL to AC, but not from AC to SCCL. Dysplasia in AC or histological grade in SCCL were not related to the reactivity of any modified histones.

CONCLUSIONS

Histone modifications are related to initial actinic damage, but not to malignant transformation in the lip.

Для цитирования: de Freitas Filho Silas Antonio Juvencio, Servato João Paulo Silva, de Sá Rodrigo Tavares, Siqueira Carla Silva, de Faria Paulo Rogério, Loyola Adriano Mota, Cardoso Sérgio Vitorino. Evaluation of specific modified histones in lip carcinogenesis.. Pathology, research and practice. 2018. DOI: 10.1016/j.prp.2018.04.004.

Предметные рубрики MeSH

Adult Aged Aged, 80 and over Carcinoma, Squamous Cell Cell Transformation, Neoplastic Cheilitis Female Gene Expression Regulation, Neoplastic Head and Neck Neoplasms Histones Humans Lip Neoplasms Male Middle Aged Squamous Cell Carcinoma of Head and Neck Young Adult

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.