American journal of cancer research · 2026
Prognostic value of systemic inflammatory and nutritional markers in patients with resectable colon cancer: a retrospective observational study.
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Zeng Fang, Wei Danyun, Zhang Zilong, Zhou Lei, Zheng Minghui, Zheng Yongbin
Аннотация
BACKGROUND: Colorectal cancer remains a leading cause of global cancer morbidity. While pathological staging is a cornerstone of prognosis, host-related factors, including systemic inflammatory response and nutritional status, are increasingly recognized as critical determinants of outcomes.
METHODS: This single-center retrospective study investigated the prognostic value of preoperative hematologic markers - neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, C-reactive protein-to-albumin ratio, prognostic nutritional index (PNI), and the Controlling Nutritional Status score - in 113 patients who underwent radical colectomy between December 2020 and June 2022. The primary and secondary endpoints were 3-year disease-free survival (DFS) and overall survival (OS), respectively.
RESULTS: The cohort demonstrated 3-year DFS and OS rates of 74.1% and 77.0%, respectively, and an overall recurrence rate of 23.9% within the follow-up period. Multivariate Cox analysis identified a high PNI (≥ 43.62) as an independent protective factor for 3-year DFS (hazard ratio [HR] = 0.057, 95% confidence interval [CI]: 0.016-0.125, P < 0.01), and a high PLR (≥ 169.27) as an independent risk factor (HR = 7.910, 95% CI: 2.048-30.558, P < 0.01).
CONCLUSION: Preoperative PNI and PLR are readily accessible, independent prognostic biomarkers for patients with resectable colon cancer. They augment traditional Tumor, Node, Metastasis staging by reflecting the critical balance between pro-tumor inflammation and host immunonutritional status within the tumor microenvironment.
METHODS: This single-center retrospective study investigated the prognostic value of preoperative hematologic markers - neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, C-reactive protein-to-albumin ratio, prognostic nutritional index (PNI), and the Controlling Nutritional Status score - in 113 patients who underwent radical colectomy between December 2020 and June 2022. The primary and secondary endpoints were 3-year disease-free survival (DFS) and overall survival (OS), respectively.
RESULTS: The cohort demonstrated 3-year DFS and OS rates of 74.1% and 77.0%, respectively, and an overall recurrence rate of 23.9% within the follow-up period. Multivariate Cox analysis identified a high PNI (≥ 43.62) as an independent protective factor for 3-year DFS (hazard ratio [HR] = 0.057, 95% confidence interval [CI]: 0.016-0.125, P < 0.01), and a high PLR (≥ 169.27) as an independent risk factor (HR = 7.910, 95% CI: 2.048-30.558, P < 0.01).
CONCLUSION: Preoperative PNI and PLR are readily accessible, independent prognostic biomarkers for patients with resectable colon cancer. They augment traditional Tumor, Node, Metastasis staging by reflecting the critical balance between pro-tumor inflammation and host immunonutritional status within the tumor microenvironment.