Digestive diseases and sciences · 2026
Sociodemographic Risk Factors in Therapy Delays and Associated Increased Mortality Among Colorectal Cancer Patients in the US: Insights from Surveillance, Epidemiology, and End Results Program.
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Ali Hassam, Moond Vishali, Dahiya Dushyant Singh, Hayat Umar, Bilal Mohammad, Shaukat Aasma
Аннотация
INTRODUCTION: We investigated the impact of racial/ethnic disparities in therapy initiation on colorectal cancer (CRC) mortality using Surveillance, Epidemiology, and End Results Program (SEER) database.
METHODS: Adults aged 18-84 years with CRC were identified. Cox models for 60-month all-cause and cancer-specific mortality were adjusted for demographics, stage, tumor site, income, and rural-urban residence.
RESULTS: Therapy initiation was slower for Hispanics (HR 0.85) and non-Hispanic Black (NHB) patients (HR 0.80) compared with non-Hispanic Whites (p < 0.001). Each additional month of delay was associated with a 3% increase in cancer mortality (p < 0.001). Findings were consistent across diagnosis eras, with no significant race-by-era interaction, and adjustment for socioeconomic and geographic factors resulted in minimal attenuation of racial disparities.
CONCLUSION: Treatment delays independently contribute to all-cause and cancer-specific mortality, disproportionately affecting NHB and lower-SES patients.
METHODS: Adults aged 18-84 years with CRC were identified. Cox models for 60-month all-cause and cancer-specific mortality were adjusted for demographics, stage, tumor site, income, and rural-urban residence.
RESULTS: Therapy initiation was slower for Hispanics (HR 0.85) and non-Hispanic Black (NHB) patients (HR 0.80) compared with non-Hispanic Whites (p < 0.001). Each additional month of delay was associated with a 3% increase in cancer mortality (p < 0.001). Findings were consistent across diagnosis eras, with no significant race-by-era interaction, and adjustment for socioeconomic and geographic factors resulted in minimal attenuation of racial disparities.
CONCLUSION: Treatment delays independently contribute to all-cause and cancer-specific mortality, disproportionately affecting NHB and lower-SES patients.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedYoung AdultBlack or African AmericanColorectal NeoplasmsHealthcare DisparitiesHispanic or LatinoRisk FactorsSEER ProgramSociodemographic FactorsSocioeconomic Disparities in HealthSocioeconomic FactorsTime-to-TreatmentTreatment DelayUnited StatesWhite