Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2016
Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis.
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Colombo Bruno da Silveira, Ronsoni Marcelo Fernando, Soares E Silva Pedro Eduardo, Fayad Leonardo, Wildner Letícia Muraro, Bazzo Maria Luiza, Dantas-Correa Esther Buzaglo, Narciso-Schiavon Janaína Luz, Schiavon Leonardo Lucca
Аннотация
CONTEXT: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown.
OBJECTIVES: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis.
MATERIALS AND METHODS: Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I ≥13 ng/mL and 63.2% for patients with IGF-I <13 ng/mL (p = .001).
DISCUSSION AND CONCLUSION: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.
OBJECTIVES: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis.
MATERIALS AND METHODS: Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I ≥13 ng/mL and 63.2% for patients with IGF-I <13 ng/mL (p = .001).
DISCUSSION AND CONCLUSION: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.