Hong Kong medical journal = Xianggang yi xue za zhi · 2012
Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap.
Контролируемое клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Chiu T W, Leung Czarina C H, Lau Edgar Y K, Burd Andrew
Аннотация
OBJECTIVE: To investigate gabapentin's role in head and neck cancer surgery following the demonstration of the effectiveness of gabapentin in reducing postoperative pain.
DESIGN: Non-randomised open-label trial.
SETTING: Prince of Wales Hospital, Hong Kong.
MAIN OUTCOME MEASURES: Pain scores, analgesic usage, and the frequency of adverse effects.
PATIENTS: In patients undergoing anterolateral thigh flap reconstruction after resection of tongue carcinoma, those who had an oral dose of gabapentin before surgery were compared to those who did not.
RESULTS: Postoperative pain was reduced in the gabapentin group (1.2) compared to the control group (1.7) [P=0.05]. In the gabapentin group, mean morphine (patient-controlled analgesia) use (3.5 mg), sedation scores (1.0), and antiemetic usage (0 mg metoclopramide) were all significantly reduced in comparison to the controls with respective figures of 11.4 mg, 1.6, and 12.2 mg.
CONCLUSION: Single preoperative doses of gabapentin led to significant reductions in postoperative pain and nausea with reduced analgesic and antiemetic usage, without additional side-effects or increases in operative complications.
DESIGN: Non-randomised open-label trial.
SETTING: Prince of Wales Hospital, Hong Kong.
MAIN OUTCOME MEASURES: Pain scores, analgesic usage, and the frequency of adverse effects.
PATIENTS: In patients undergoing anterolateral thigh flap reconstruction after resection of tongue carcinoma, those who had an oral dose of gabapentin before surgery were compared to those who did not.
RESULTS: Postoperative pain was reduced in the gabapentin group (1.2) compared to the control group (1.7) [P=0.05]. In the gabapentin group, mean morphine (patient-controlled analgesia) use (3.5 mg), sedation scores (1.0), and antiemetic usage (0 mg metoclopramide) were all significantly reduced in comparison to the controls with respective figures of 11.4 mg, 1.6, and 12.2 mg.
CONCLUSION: Single preoperative doses of gabapentin led to significant reductions in postoperative pain and nausea with reduced analgesic and antiemetic usage, without additional side-effects or increases in operative complications.
Предметные рубрики MeSH
Administration, OralAdultAgedAged, 80 and overAminesAnalgesia, Patient-ControlledAnalgesicsAntiemeticsCohort StudiesCyclohexanecarboxylic AcidsFemaleFree Tissue FlapsGabapentinHong KongHumansMaleMiddle AgedMorphinePain MeasurementPostoperative PainPostoperative Nausea and VomitingPreoperative CarePlastic Surgery ProceduresRetrospective StudiesThighTongue Neoplasmsgamma-Aminobutyric Acid