Head & neck · 2011
Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer.
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Han Myung Woul, Lee Hee Jin, Cho Kyung-Ja, Kim Jae Seung, Roh Jong-Lyel, Choi Seung-Ho, Nam Soon Yuhl, Kim Sang Yoon
Аннотация
BACKGROUND: To determine whether 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) could serve as a useful technique predicting tumor hypoxia and prognosis in tongue cancer, we assessed the relationship between FDG uptake and the levels of hypoxia-related markers.
METHODS: Tumor uptake of FDG in 33 patients with T2 tongue cancer was assessed by measuring maximum standardized uptake values (SUVmax). Expression of hypoxia-inducible factor (HIF)-1α, carbonic anhydrase (CA)-9, glucose transporter (GLUT)-1, and erythropoietin receptor (EPOR), was determined by immunohistochemical staining. Correlation between SUVmax and the expression of hypoxia-related markers was assessed and multivariate analysis was performed to determine what parameters affected clinical outcomes.
RESULTS: We observed strong correlations between SUVmax and expression of HIF-1α (p < .05), CA-9 (p < .01), and GLUT-1 (p < .01). SUVmax, HIF-1α expression, and tumor grade were significant independent predictors of disease-free survival (DFS).
CONCLUSION: SUVmax may be a good noninvasive biomarker for prediction of hypoxic status and prognosis of patients with T2 tongue cancer.
METHODS: Tumor uptake of FDG in 33 patients with T2 tongue cancer was assessed by measuring maximum standardized uptake values (SUVmax). Expression of hypoxia-inducible factor (HIF)-1α, carbonic anhydrase (CA)-9, glucose transporter (GLUT)-1, and erythropoietin receptor (EPOR), was determined by immunohistochemical staining. Correlation between SUVmax and the expression of hypoxia-related markers was assessed and multivariate analysis was performed to determine what parameters affected clinical outcomes.
RESULTS: We observed strong correlations between SUVmax and expression of HIF-1α (p < .05), CA-9 (p < .01), and GLUT-1 (p < .01). SUVmax, HIF-1α expression, and tumor grade were significant independent predictors of disease-free survival (DFS).
CONCLUSION: SUVmax may be a good noninvasive biomarker for prediction of hypoxic status and prognosis of patients with T2 tongue cancer.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkersBiopsy, NeedleCarbonic AnhydrasesCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleFluorodeoxyglucose F18Follow-Up StudiesHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeck DissectionPeptide FragmentsPositron-Emission TomographyPredictive Value of TestsPreoperative CareProportional Hazards ModelsReceptors, ErythropoietinRegistriesRetrospective StudiesRisk AssessmentSurvival AnalysisTongue NeoplasmsTreatment Outcome