Annals of surgical oncology · 2025
Demographic and Clinicopathologic Characteristics of 3723 Patients with Primary Oral Squamous Cell Carcinoma: A Consecutive, Single-Center Study Over 11 Years (2012-2023).
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Xiao Yao, Cao Lei-Ming, Zhu Zhao-Qi, Wang Xiao-Hu, Wang Guang-Rui, Zhou Kan, Yu Yi-Fu, Zhang Yi-Jia-Ning, Shen Ke-Ru, Liu Jing-Yi, Li Zi-Zhan, Liu Xuan-Hao, Luo Han-Yue, Zhang Si-Jie, Wang Kang-Ning, Mak Chon-Hou, Wei Li-Ya, Ma Zhi-Gong, Liang Run-Feng, Wei Hao, Xu Zhen-Yu, Wang Wei-Yu, Qiu Yu-Zhong, Tang Yun, Xiong Xue-Peng, Jia Jun, Bu Lin-Lin, Liu Bing
Аннотация
OBJECTIVE: This study aimed to investigate the demographic and clinicopathologic characteristics of oral squamous cell carcinoma (OSCC) and explore the risk factors associated with OSCC pathological TNM (pTNM) stage.
METHODS: This retrospective study included patients with OSCC from 2012 to 2023. Data analyzed included demographics, clinicopathological characteristics, and treatment. Age differences were analyzed using the Mann-Whitney U test. Categorical variables were presented as percentages and were compared using the Chi-square or Fisher's exact tests. Logistic regression was used for multivariate analysis.
RESULTS: A total of 3723 patients were analyzed and the male:female ratio was 2.35:1. Patients aged 45-59 years accounted for the largest proportion (37%, 1377/3723) of patients, and 90.7% (3375/3723) were from Hubei Province of China. The most commonly affected site was the body of the tongue (45.8%, 1704/3723). Moderately differentiated OSCC patients accounted for 54.9% (2045/3723) of the study cohort. The percentage of patients with locally advanced-stage OSCC (pTNM stage III/IV) was 41.2% (1534/3723). Patients of different sexes with OSCC at different sites were statistically different in respect to clinicopathological characteristics. 3057 patients underwent neck dissection, while 39.3% (1201/3057) had positive lymph nodes. Alcohol consumption, age >50 years, and perineural invasion (PNI) were independent risk factors for locally advanced OSCC (p < 0.05).
CONCLUSIONS: OSCC is more common in males and the most common site was the body of the tongue. Alcohol consumption, age > 50 years, and PNI were independent risk factors for locally advanced OSCC. The limitations include selection bias from a single-center study and the lack of prognostic data. Future studies should explore OSCC heterogeneity and enhance preventive strategies for patients who had risk factors.
METHODS: This retrospective study included patients with OSCC from 2012 to 2023. Data analyzed included demographics, clinicopathological characteristics, and treatment. Age differences were analyzed using the Mann-Whitney U test. Categorical variables were presented as percentages and were compared using the Chi-square or Fisher's exact tests. Logistic regression was used for multivariate analysis.
RESULTS: A total of 3723 patients were analyzed and the male:female ratio was 2.35:1. Patients aged 45-59 years accounted for the largest proportion (37%, 1377/3723) of patients, and 90.7% (3375/3723) were from Hubei Province of China. The most commonly affected site was the body of the tongue (45.8%, 1704/3723). Moderately differentiated OSCC patients accounted for 54.9% (2045/3723) of the study cohort. The percentage of patients with locally advanced-stage OSCC (pTNM stage III/IV) was 41.2% (1534/3723). Patients of different sexes with OSCC at different sites were statistically different in respect to clinicopathological characteristics. 3057 patients underwent neck dissection, while 39.3% (1201/3057) had positive lymph nodes. Alcohol consumption, age >50 years, and perineural invasion (PNI) were independent risk factors for locally advanced OSCC (p < 0.05).
CONCLUSIONS: OSCC is more common in males and the most common site was the body of the tongue. Alcohol consumption, age > 50 years, and PNI were independent risk factors for locally advanced OSCC. The limitations include selection bias from a single-center study and the lack of prognostic data. Future studies should explore OSCC heterogeneity and enhance preventive strategies for patients who had risk factors.