Laryngoscope investigative otolaryngology · 2017
The Benefit of Adjuvant Radiation in Surgically-Treated T1-2 N1 Oropharyngeal Squamous Cell Carcinoma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Monroe Marcus M, Buchmann Luke O, Hunt Jason P, Hitchcock Ying J, Lloyd Shane, Hashibe Mia
Аннотация
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear.
OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation.
STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011.
SETTING: Population-level study.
PARTICIPANTS: Patients with T1-2N1 OPSCC treated with surgical resection and neck dissection with or without adjuvant radiation.
INTERVENTIONS FOR CLINICAL TRIALS OR EXPOSURES FOR OBSERVATIONAL STUDIES: The use of postoperative adjuvant radiation.
MAIN OUTCOMES AND MEASURES: Overall and disease-specific survival.
RESULTS: Radiation was utilized in 74% of patients and was positively associated with extracapsular extension and well-differentiated histology. The use of radiation was associated with improved mean overall survival (124 v. 108 months, p=0.023) and a non-significant increase in mean disease-specific survival (138 v. 131 months, p=0.053).
CONCLUSIONS AND RELEVANCE: The use of adjuvant radiation is associated with improved survival in surgically-treated T1-2N1 squamous cell carcinoma of the oropharynx with unknown HPV status.
LEVEL OF EVIDENCE: IV.
OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation.
STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011.
SETTING: Population-level study.
PARTICIPANTS: Patients with T1-2N1 OPSCC treated with surgical resection and neck dissection with or without adjuvant radiation.
INTERVENTIONS FOR CLINICAL TRIALS OR EXPOSURES FOR OBSERVATIONAL STUDIES: The use of postoperative adjuvant radiation.
MAIN OUTCOMES AND MEASURES: Overall and disease-specific survival.
RESULTS: Radiation was utilized in 74% of patients and was positively associated with extracapsular extension and well-differentiated histology. The use of radiation was associated with improved mean overall survival (124 v. 108 months, p=0.023) and a non-significant increase in mean disease-specific survival (138 v. 131 months, p=0.053).
CONCLUSIONS AND RELEVANCE: The use of adjuvant radiation is associated with improved survival in surgically-treated T1-2N1 squamous cell carcinoma of the oropharynx with unknown HPV status.
LEVEL OF EVIDENCE: IV.