Infection · 2021
Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Billon-Denis Emmanuelle, Ferrier-Rembert Audrey, Garnier Annabelle, Cheutin Laurence, Vigne Clarisse, Tessier Emilie, Denis Jessica, Badaut Cyril, Rougeaux Clémence, Depeille Wuille Anne, Timera Hawa, Boutin Laet Itia, Drouet Isabelle, Verguet Noémie, Nolent Flora, Gorgé Olivier, Ferraris Olivier, Tournier Jean-Nicolas
Аннотация
BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.
CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.
DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.
DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.