Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2020
A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful.
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Hirouchi Takatomo, Ota Shinichiro, Mashima Dai, Boku Ryuichi, Yoshida Yuto, Iwata Koki, Shinada Kanako, Matsumoto Takashi, Morikawa Miwa, Sato Takashi, Shinoda Masahiro, Kamachi Kenichi, Shinkai Masaharu
Аннотация
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.