Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022
Liver, NAFLD and COVID-19.
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Hoffmann Carlotta, Gerber Philipp A, Cavelti-Weder Claudia, Licht Louisa, Kotb Reham, Al Dweik Rania, Cherfane Michele, Bornstein Stefan R, Perakakis Nikolaos
Аннотация
Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum that includes abnormalities in liver function indicative of liver damage. Conversely, people with liver diseases are at higher risk of severe COVID-19. In the current review, we summarize first the epidemiologic evidence describing the bidirectional relationship between COVID-19 and liver function/liver diseases. Additionally, we present the most frequent histologic findings as well as the most important direct and indirect mechanisms supporting a COVID-19 mediated liver injury. Furthermore, we focus on the most frequent liver disease in the general population, non-alcoholic or metabolic-associated fatty liver disease (NAFLD/MAFLD), and describe how COVID-19 may affect NAFLD/MAFLD development and progression and conversely how NAFLD/MAFLD may further aggravate a COVID-19 infection. Finally, we present the long-term consequences of the pandemic on the development and management of NAFLD.