Oncology · 2026
Multicenter Study on the Safety and Efficacy of First-Line Nivolumab-Combination Chemotherapy in Patients Aged 75 Years and Older with Unresectable Advanced or Recurrent Gastric Cancer.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kimura Akiharu, Sano Akihiko, Nakazawa Nobuhiro, Kumakura Yuji, Yamashita Toshiki, Tanaka Naritaka, Saito Kana, Ogata Kyoichi, Kasuga Kengo, Nakazato Kenji, Yoshinari Daisuke, Shimizu Hisashi, Ubukata Yasunari, Hosaka Hisashi, Okada Takuhisa, Shiraishi Takuya, Sakai Makoto, Shirabe Ken, Saeki Hiroshi
Аннотация
INTRODUCTION: Nivolumab combined with chemotherapy has been approved as the first-line treatment for HER2-negative, unresectable, advanced, or recurrent gastric cancer. Patients aged ≥75 years have impaired organ function and comorbidities that increase the risk of adverse events, including immune-related adverse events more often than younger patients, potentially limiting the continuation of treatment. In this multicenter study, we aimed to evaluate the safety and efficacy of first-line nivolumab chemotherapy in older patients.
METHODS: We retrospectively analyzed data from 103 patients treated with first-line nivolumab combination chemotherapy for unresectable, advanced, or recurrent gastric cancer at 12 institutions between November 2021 and January 2023. The participants were divided into groups A (<75 years, n = 67) and B (≥75 years, n = 36).
RESULTS: The mean age was 63.9 years in Group A and 78.6 years in Group B. Body weight was significantly lower (p = 0.041), and performance status 0-1 and hypertension were more prevalent in Group B (both p < 0.01). Chemotherapy regimens and incidence of grade ≥3 immune-related adverse events were similar between the groups. The median overall survival was 15.2 months in Group A and was not reached in Group B; this difference was not significant (p = 0.689).
CONCLUSIONS: First-line chemotherapy with nivolumab is safe and effective in patients aged ≥75 years with a good performance status, as in younger patients, suggesting that it is a valid treatment option for the former subgroup.
METHODS: We retrospectively analyzed data from 103 patients treated with first-line nivolumab combination chemotherapy for unresectable, advanced, or recurrent gastric cancer at 12 institutions between November 2021 and January 2023. The participants were divided into groups A (<75 years, n = 67) and B (≥75 years, n = 36).
RESULTS: The mean age was 63.9 years in Group A and 78.6 years in Group B. Body weight was significantly lower (p = 0.041), and performance status 0-1 and hypertension were more prevalent in Group B (both p < 0.01). Chemotherapy regimens and incidence of grade ≥3 immune-related adverse events were similar between the groups. The median overall survival was 15.2 months in Group A and was not reached in Group B; this difference was not significant (p = 0.689).
CONCLUSIONS: First-line chemotherapy with nivolumab is safe and effective in patients aged ≥75 years with a good performance status, as in younger patients, suggesting that it is a valid treatment option for the former subgroup.